A comprehensive systematic review and meta-analysis of pharmacological and dietary supplement interventions in paediatric autism: Moderators of treatment response and recommendations for future research

A Masi; A Lampit; MM Demayo; N Glozier; IB Hickie; AJ Guastella

Journal article

A comprehensive systematic review and meta-analysis of pharmacological and dietary supplement interventions in paediatric autism: Moderators of treatment response and recommendations for future research

A Masi, A Lampit, MM Demayo, N Glozier, IB Hickie, AJ Guastella

Psychological Medicine | CAMBRIDGE UNIV PRESS | Published : 2017

DOI: 10.1017/S0033291716003457

Abstract

Background Autism spectrum disorders (ASDs) are pervasive and multifactorial neurodevelopmental conditions, characterized by impairments in social communication and interaction, and restricted, repetitive patterns of behaviour, interests or activities. Treatment options to ameliorate symptoms of ASDs are limited. Heterogeneity complicates the quest for personalized medicine in this population. Our aim was to investigate if there are baseline characteristics of patients that moderate response or trial design features that impede the identification of efficacious interventions for ASDs. Method Literature searches of EMBASE, MEDLINE and PsycINFO identified 43 studies for qualitative assessment ..

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University of Melbourne Researchers

Amit Lampit Author

Related Projects (1)

MOVING BEHAVIOURAL NEUROSCIENCE &AMP; NEUROECONOMICS INTO DEMENTIA PREVENTION: SPATIAL TRACKING AND ECONOMIC DECISION-MAKING AS NEW SENSITIVE MEASURES OF DAILY FUNCTION

This project will aim to develop new measures for clinical trials by learning the relationship between older people's movements around the h..

Grants

Awarded by National Health and Medical Research Council (NHMRC) Dementia Research Development Fellowship

Awarded by NHMRC

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

The authors thank Professor Salvador-Carulla for his comments on the manuscript, Harry Hallock for assisting with analysis and presentation of data and Kerribeth Szolusha for assisting with data extraction and the evaluation of study quality. The authors acknowledge a National Health and Medical Research Council (NHMRC) Dementia Research Development Fellowship (ID 1108520) to A.L. and a NHMRC career development fellowship (APP1061922) and project grant (1043664) to A.J.G.